Yes, this should be possible..
If all displays are configured as extended desktops, you could show 3 different things on each display..
I saw the Nvidia software is able to control which *.exe to show on which display.. but I don't know if that is compatible with centrafuse..
Then there is the audio thing..
If you play music on the rear right screen, you want the sound there too.. that would be area 1
DVD on rearleft would be area 2
and the nav on the front screen would be area 3..
I don't think Windows is able to have 3 different audio streams, moving through 1 soundcard.. Maybe multiple soundcards?
I know Centrafuse is able to shoot sound at different soundcards...
There it is.. Don't for sure, but with some experimenting you could come a long way..