You probably have this problem. There's a "beta expired" window in the background that you can't see because you probably have "always on top" set. It happened to me too.
Everything was running great til yesterday, when Centrafuse loaded the splash screen, said it was initializing, but then just got stuck. I thought it might just be taking longer than usual, but still failed to initialize after my 20 minute commute. I'm running CF 1.4 right now, but maybe I should upgrade to 1.5? Anyone else have this issue?