In that case (if using EWF and HORM) there is no advantage to install Centrafuse to another unprotected partition.
If not using HORM, but usual hibernation, a problem is if you are using removable drive for media -> there is no advantage having removable one, because when resuming all new data on removable drive will be corrupted.

For now I installed Centrafuse on C: as usual, and everytime I resume, it resumes from the same state and I have to load media again (few clicks). When turning off the system, "shut down" is selected (it takes about 2 seconds).