If you are talking about Palmer Performance, then the answer is no. Their software is for reading OBDII, not writing anything back to the car. Depending on the make/model of the car, you can buy a handheld tuner for around $300 and probably a custom tune from the same distributor for a little more. SCT is a very popular tuner hardware/software manufacturer, and they make very good tuners.
AFAIK, there is no carpc + frontend solution. I believe there are pc solutions available, but they are very expensive and you pretty much have to be a distributor or a tuner to get it, from what I recall anyway.