I cant tell you what your best option would be without looking at how your A/c controls operate in the first place, but if it's all electrical then you really won't have a problem relocating it. In my case (GMC sonoma) I couldn't relocate the controls too far from their stock location due to it being controlled via vacuum. Instead of opting to relocate them to the glovebox like the majority of people do however, I'm working on fiberglassing them into the ashtray.
If your AC is completely electric then it owuld be nothing more than extending some wires to relocate it. Easy work.
If your wondering about the best way to make everything fit into your dash, take the old bezel off and seal every sigle nook and cranny via 3/4oz. fiberglass and epoxy resin with a wood backing to fill all the holes. Cut the wood to fit, and lay the fiberglass down on each side of it to "pancake" it inbetween. After that, epoxy/fiberglass the ac bezel to the wood piece as well as the screen bezel, and make a plan on how you'll mount everything. If your lucky you'll have ac controls with a front plastic piece and an actuall thicker support piece that screws onto the front bezel. Fiberglass the front bezel to the wood base and use the thicker support piece to hold all the controls, so that you can just screw it onto the front bezel.
After that lay some spandex over everything, then start layering up the fiberglass until you've got something suitable.