Sure. You just use a relay for each set of lights you want to turn on/off. This may help:
Ok First of all i know this is a forum dedicated to cars, but im having a hard time understanding how to use this in home automation. I want to be able to turn off the lights in my room via my HTPC. Can i just use the 25a relays and somehow hook up the lights to my light switches? Not very good with electrical knowledge.
thats kind of what i figured, thanks for the site >.< lol @ wiki.