1. Wine is buggy.
2. Many of us aren't using GUIs.
3. Fusion's MDX is far from efficient
4. MDX can't communicate with linux apps.
In theory it could work but it defeats the purpose of linux in the car.
If you are interested in running the fusion software, give it a shot. Let us know how it goes. I believe the only gotcha will be mapping the linux serial device to a com port, but WINE offers a tool which should handle that.