Hard drives are quite smart, They monitor rotational speed spin up times and all sorts of other things about the physical workings of a hard drive. You probably won't have to deal with data loss from thing's being "out of sync", but it's possible that the platters will not be able to spin up enough to allow the head's to rise from the disk platters. This would lead to you quickly griding the head's to dust and destroying the hard drive.
I have a feeling though that the drive probably has fail-safes to prevent you from doing physical damage to the disk.
Personaly I'd get a different drive, one that doesn't have fluid bearings.