Nope.. not as long as your parts are securely fastened down. The only problem you might have would be with electrical interference. Metal computer cases are designed to shield against this stuff, but acrylic provides little, if any, shielding. This may not be a big problem depending on where you put your player and if you ground your power supply, etc., but you may want to talk to other people with "alternative" cases and see how their setup performs.



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