Yes it is possible. Basically you will need 4 video cards if you are wanting video, each with an output. Then use windows Extended Desktop onto it. The problem you will have is that windows doesn't like to play video on dual monitors let alone 4. If you have 2 monitors, it turns one half black, the other has video. There is an option to not let that happen but I forget what it it. Under Display Properties' advanced tab I believe.
Oh, and for that, you better have a fast setup!