I dont know about Citizens Band, but I know in Amature Radio, there are many radios that interface with computers for computer control. I actually have a 2 meter radio in my work car that has computer interface port. But you have to have a amature radio license to operate it. (KD5TSJ) And its no where near Citizens band. But you are free and clear on CB, as long as you can find the radio. Another option is to just use your line in and Mic ports on your computer. You would just have to set up a relay to tell the radio that you are transmiting. And you would have to have some audio isolation transfomers on the lines, so your audio will be compatiable.