Yes, I do this myself. I actually have it setup to use F13-F24 (not all, but most) to differentiate between the buttons. I use Meedio which accepts messages so it is a relatively seemless process. Girder listens for the F keysa nd then sends the appropriate message to Meedio. I have the outer dial set to repeat the keys faster and faster. Not sure how RR works as I've never used it. Worst case you can set the target to RR and send the keystrokes.