To fixed the problem (not 100% but at least work for me)
- Get the latest USB to Serial driver from Delorme website.
- Do not share the GPS and WiFi adapter on the same hub. Just GPS, Touchscreen, Mouse/keyboard.
Optional but usefull
Search the forum for Xport2 (not Xport) and Compass and install that 2 software. It will help the GPS wake up after hibernate. That pieces of software wrote by Curiosity on this forum.