Are you going through a hub? When I first got my Royaltek Sapphire GPS receiver, it caused a major system crash when coming out of standby. I had it running through a self-powered USB hub coming off a line from the Opus, so the power was killed when it entered standby.
To fix this, I just moved the receiver to the back and plugged it straight into a USB port on the mobo. Now it enters standby and comes back lickity split. Give it a shot.