It installs just fine and runs without any tweak. But...
To get it to work with my USB GPS I had to recompile Wine using the comm.c file from release 0.9.22 into the 1.1.11 distribution.
I could see the NEMA data with any windows terminal application using a com port linked to my device (/dev/ttyACM0 in my case), but iGuidance would not detect the GPS. It has something to do with IOCTL mode that got removed from the comm.c file in the more recent versions of wine.
To display the street names properly I had to install ms core fonts (using Winetrick).
To get the sound to work I had to play around with TTS (text-to-speech) from Microsoft (had to install it).