Well I installed the latest crossover office demo and made the symlink ln -s /dev/ttyUSB0 com1 (which I found out the com1 has to be lower case). And the results are in the image below.
iGuidance 3 runs in linux under crossover-standard-demo-5.0.3. I haven't done any detailed testing but from the few minutes I've played with it it seems to work.
I'm running the iGuidance UMPC.
It appeared to crash after a while while I was clicking on things.
Performance seems to be great. You would think it was a native app.
I guess the trick now is to find out how to prevent it from crashing.
Edit: I wonder if crossover office demo has a nag screen. It is possible that poping up (though I haven't actualy seen one pop up) could be a problem.
Is it stable for you other guys?