I'm glad I found this thread. Here's my deal:
I've got an Asus Eee with eeeXubuntu (7.10), and a Holux GR-213u. The GPS unit works fine in xgps and GpsDrive.
I've got iGuidance3 installed via CXOffice. It runs fine, but GPS info shows nothing (other than Lat/Long data, which seems relatively correct but unconfirmed). I've done the appropriate /dev/ttyUSB0 -> dosdevices/com2 linkage.
I figure I've got the same comm issue you've been talking about with Wine. Wondering if you can hook my up with your .deb file.
For the record, I had Wine 0.9.46. I just installed 0.9.54 (via the wineHQ apt source), still no dice.
I just had a thought... I don't think CXOffice uses the normal Wine install. Perhaps I should try Wine instead of CXOffice. Can you hit me with your .deb anyway? thx