Well, there might be something to it, but I can't give you a difinite yes or no. I know that Cadillacs are crazy integrated, and if you pull the radio in certain models things can go haywire. I guess what I would do is pull the radio out, drive around without it for a couple of days, and if nothing bad happens then go ahead with your carputer install. If something does go haywire, just put the radio back in. No harm, no foul.