The simplest is to run power wires along whatever side of the car the battery is on.
Run the audio lines down the other side.
That's really going to depend on where everything is going to be mounted.-how close should i place my Power Distributor Block to my amps (i want to know in order to know how much wire to buy)
Again, that's up to you.-and last question is should i get some EQ, Line Drivers and Crossovers from AudioControl? or is this a waste of money and over kill?
I use a Three.1 (now the Four.1), but I also don't use a headunit, either.
Granted, I'm very pleased w/ the AudioControl EQ for what it does in my system.
I can't say if it would add to your setup, though.