since everything on a mobo is solid-state, i think you'll be fine, with one exception: the heatsink/fan. I'd be concerned with it possibly shaking loose depending on its own size/weight. If its nice and light, you'll probably be fine, but if its not, then you might want to figure out a way of better securing it. I think it be better if the board layed flat, so it could bear the weight of the HSF straight on, instead of it hanging, but that might still not be enough. another thing to think about is the magnents in the subs. 10 inch subs have got some hefty magnents and they might **** off the motherboard. But that is just a thought as I don't really know what i am talking about. hope i helped,
ray



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