I think it would be up to your speaker system in the car. I know from my own experience with boston acoustics, this is the case since they use crossovers and therefore all hook up separately. This is just one part of the equation though. Unfortuantely for the second part, at least for me, I noticed that you need an amp that specifically has rca connections for your separate speakers. Looking at mine, I only have L/R for front/rear, but if you can find an amp that does hat you're asking, it should work.