software only version will work with any NMEA compatible receiver. the catch with it tho, is that it can only be used on one computer. So to install on multiple computers, u must deregister it before installing. The version that come with the receivers allows you to install it as many times on any computer, but it will only work with the designated receiver that came with the purchase. I use the 20x usb receiver that comes with GMPC. Hasn't failed me yet; but Im almost positive the BU-353 can be used with the software only version.