as for the efficiency, yes, you are correct. efficiency is power out divided by power in. so at 250W out, you will need 416W coming in. that also means you're dissipating the difference in the converter... 167 watts of heat.
and no, efficiency is not related to voltage regulation.
a DC-DC should be relatively tolerant of voltage spikes. there are large inductors and capacitors in it, not to mention active voltage control by the circuitry... all of those things act against power spikes.
as long as you operate it within specs, it should have no problems with output voltage, and you should not need a separate voltage regulator. after all, that is the job of a DC-DC... providing a constant output voltage with various input voltages.



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