Okay more weirdness . . .
I installed Road Runner and radioSHARK and the plugin on a different computer (the desktop at work) which is running windows 2000 server and guess what.
Then I copied the entire Griffin Folder and Road Runner Folder from the desktop, and copied it to the machine that I can't get it to run on . . . and guess what . . .
Nothing. Still won't run. The skin comes up, but no dice.
So, it appears to be a hardware thing. Are there any dll tips or anything I should check to make the plugin run? DirectX? .NET framework?