I just cannot figure out what is going on with your setup so the only thing I can think of is start over.
Ok make sure you have at least 7-8-06 version of RR.exe
Rename your Chucks folder - ChucksOld
Down load CkucksSKINIIII.zip and unzip and make sure everything is new – just redid it today
Then open RR and select Chucks Skin then quit RR and restart RR to make sure Chucks skin starts as soon as RR starts.
Go to setup and try to change button preset 1 and save preset 1 then quit RR and restart and see if the setting you saved work and let me know.