blk, I see that you have a non-standard installation location for RR. Did you use the Install Shield or did you install RR manually?
Also, what version of RR do you use?
This might fix it but it's just temporary until liquid_smokes comes out with a new release. Create a folder like this.
C:\Program Files\Road Runner\
Then in E:\Road Runner\ you should see a file called exec.exe. Copy it over to C:\Program Files\Road Runner\.