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Mixing and matching is not always bad, but don't put them in the same box. ie: having a set of 12's in the trunk and also some 10's under the rear seat. But having 1 10 and 1 12 in the same box is going to give you a weird bass setup. And that current 400w amp is not going to be nearly enough to power a decent 12 sub. I'm running 1 12" Alpine Type R powered by a 500w Alpine amp. And that's still not the max output of the sub. Do some research on some better brands of subs and amps before just swapping out for a 12".
Look into Alpine Type R's, JL W's (any of the W series hit hard, especially the new W7's), and the new Boston Acoustic subs. Also if you're going to upgrade, make sure you upgrade your amp and get it professionally tuned.
Good luck
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