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The m2-atx is rated for 160watts, so I would recommend running 10 or 12gauge wire. I personally will be using 10 gauge wire, just because it was economical for me to purchase.
12 or 14 gauge wire will work fine as well, especially if your not using the m2-atx to its rated limits. You can either attach a new spade connector to the end of your wire, or use a butt splice to connect your wire to the short wires that are included with the package.
The most important thing to do is look for some wire that has a thicker plastic covering then "normal" wire at the same gauge. This helps to protect the wire better in a car environment, and reduces the chance of a short happening because of rubbing or sharp metal.
PS. Why the DC-DC regulator? The m2-atx has very decent regulation on the output voltages it products.
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