I have the same exact issue with the M2-ATX. In the morning the thing just wont post. I have to remove the 12V cable, then reattach. After that it works the rest of the day, but same issue every morning. I have tried to cut the 12v with a switch before i let the car set for the night (no luck). I have removed all usb, dvd, etc (no luck). I just cant see the M2 not being able to handle a Via C7 and 3.5" HD. I have seen posts stating there is a defect in the M2 that causes this. Can anyone confirm this?

Jetway VIA C7 1.5GHz Mini-ITX