Not sure I totally understand. The IRMan is a receiver, it isn't able to transmit data.
However if you are looking at trying to control software with a normal (TV,Video,etc) remote control and the IRMan plugged into a PC, then there should be a wealth of software out there. Try looking at the evation web site:
http://www.evation.com/software/windows.html
Not sure how much of it is skinnable though, but once it's setup you don't generally need to play with it again.