You need sysprep, unless both systems have the same motherboard.
Windows does not like being moved to completely different system. Sysprep is one way around the problem.
The guide I mentioned earlier:
http://www.hardforum.com/showthread.php?t=772307
Oh, if you mean any hardware issues, there shouldn't be any. The only thing to take note of is that it's recommended to format the drive orientated the same way as you'll be running it. I.E. if you're running the harddrive vertically to reduce the risk of a head crash, you should to format it with the drive vertical.