I have been running two Lilliputs for the last two weeks without any major problems. The only problem i had was when i launched a program, some programs wanted to come up on the primary display, when i wanted it to start on the secondary. Someone here pointed me to a program called 'UltraMon'
http://www.realtimesoft.com/ultramon/
That program fixed all my little problems with windows placement, but for a price ... $40.
I run MediaCar on one monitor while running external apps.. (movies, etc.) on another.
I'm using a Matrox 450, i hear others video cards will work as long as your OS will handle the dual display.