This is my plan too 5.1 surround cambridge, sub box up front under dash. My logic was that the amp (built into sub at the moment) runs on 13.5 volts and basically sounds awsome in my room so cant imagine it sounding pants in car. N.b. I am a 'newbie' too, so may prove my self wrong yet, system still bench building. but if it is crap I have lost nothing and will have learnt lots.
I too have felt 'scared' of suggesting this on this board as most people seem to have proper car audio systems and thats fine. I' sure many of the people on this board were into car ICE in the traditional sense long before they started carputering and so makes perfect sense to intergrate into existing system, I would do the same. For me at the moment my interior is a shell not even a cassett deck! i cant afford a full car audio system as my car is a classic and I still have lots of work to do on it (mainly interior). Also having no interior at present means intergarting stuff isnt such a problem as for some who have modern plastis interiors, i have no carpet yet and no panels, i will design it all around the system.
Basically mate do what you think best try it, if you are not happy with it, change it. I think everyone here will agree with that. This site is all about designing tailored sytems for yourself, your spec, your requirments. Thats the whole concept avoiding paying 1000's for off the shelf crap that doesnt do exactly what you want anyway.
Have fun